The world number one made it eight straight wins in Cincinnati by easing past Carreno Busta 6-3 6-4 at the ATP Masters 1000 event.
Djokovic was in control throughout against the Spaniard, maintaining his perfect record against Carreno Busta with a third win.
The defending champion and 16-time grand slam winner will face Frenchman Lucas Pouille in the quarter-finals.
Djokovic won 12 straight points during the opening set, including breaking serve in the sixth game with a forehand pass at the net.
It was a clean first set from the Serbian star as he combined 13 winners with just five unforced errors.
Carreno Busta squandered opportunities early in the second set and he pulled a cross-court forehand wide to be broken in the third game.
Despite a much tighter set, that break was all Djokovic needed as he moved into the last eight.
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